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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-2-8
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pubmed:abstractText |
The arginine- to-glutamine change at codon 3500 of the apolipoprotein B-100 (apo B) is a well- known genetic cause of hypercholesterolemia. Since increased cholesterol levels lead to atherosclerosis, identification of the carries of the apo B-3500 mutation is an important step in the risk stratification of individuals and families with hypercholesterolemia. The prevalence of this mutation in Turkish population is not well known. We aimed to investigate the frequency of apo B-100 mutations (codon 3500) C9774T (Arg 3500-->Trp) and G9775A (Arg 3500-->Gln) in patients with atherosclerosis in comparison with healthy subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1308-0032
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-9
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pubmed:meshHeading |
pubmed-meshheading:18258526-Adult,
pubmed-meshheading:18258526-Apolipoprotein B-100,
pubmed-meshheading:18258526-Case-Control Studies,
pubmed-meshheading:18258526-Cholesterol,
pubmed-meshheading:18258526-Cholesterol, LDL,
pubmed-meshheading:18258526-Coronary Artery Disease,
pubmed-meshheading:18258526-Cross-Sectional Studies,
pubmed-meshheading:18258526-DNA,
pubmed-meshheading:18258526-European Continental Ancestry Group,
pubmed-meshheading:18258526-Female,
pubmed-meshheading:18258526-Humans,
pubmed-meshheading:18258526-Hypercholesterolemia,
pubmed-meshheading:18258526-Intracranial Arteriosclerosis,
pubmed-meshheading:18258526-Male,
pubmed-meshheading:18258526-Middle Aged,
pubmed-meshheading:18258526-Point Mutation,
pubmed-meshheading:18258526-Polymerase Chain Reaction,
pubmed-meshheading:18258526-Polymorphism, Genetic,
pubmed-meshheading:18258526-Prevalence,
pubmed-meshheading:18258526-Triglycerides,
pubmed-meshheading:18258526-Turkey
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pubmed:year |
2008
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pubmed:articleTitle |
Absence of apolipoprotein B-3500 mutation in Turkish patients with coronary and cerebrovascular atherosclerosis.
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pubmed:affiliation |
Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey.
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pubmed:publicationType |
Journal Article
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