Source:http://linkedlifedata.com/resource/pubmed/id/18257809
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-2-8
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| pubmed:abstractText |
S100A12 is a ligand for the receptor for advanced glycation end products. It has been shown that S100A12 induces expression of adhesion molecules, and mediates activation and migration of monocytes/macrophages. Circulating S100A12 may be involved in chronic inflammation. We previously reported increased S100A12 levels in patients with non-insulin-dependent diabetes mellitus and hemodialysis. A high peritoneal solute transport rate may be associated with encapsulating peritoneal sclerosis and mortality. We measured plasma S100A12 levels in peritoneal dialysis patients and evaluated a possible relation between the increased plasma S100A12 levels in peritoneal dialysis patients and the high peritoneal solute transport rate. Subjects included 36 patients (mean age +/- SE, 46.0 +/- 12.0 years) with no apparent infection and no malignancy who had been undergoing peritoneal dialysis for 36.5 +/- 3.9 months. We developed an enzyme-linked immunosorbent assay system to measure plasma S100A12 levels. A peritoneal equilibrium test was performed and subjects were categorized as high and high-average (H) (n = 14) or low and low-average (L) (n = 22) transporters. Plasma S100A12 concentrations were significantly higher in peritoneal dialysis patients (21.6 +/- 3.0 ng/mL) than in control subjects (n = 42; 10.8 +/- 1.0 ng/mL). Plasma S100A12 concentrations were also higher in the H group (28.2 +/- 6.1 ng/mL) than in the L group (14.2 +/- 2.0 ng/mL). These results suggest that S100A12 may be a sensitive marker of subclinical inflammation and that an increased S100A12 level may be related to the high peritoneal solute transport rate.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1744-9987
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
28-32
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| pubmed:meshHeading |
pubmed-meshheading:18257809-Adult,
pubmed-meshheading:18257809-Biological Transport,
pubmed-meshheading:18257809-Chronic Disease,
pubmed-meshheading:18257809-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18257809-Female,
pubmed-meshheading:18257809-Humans,
pubmed-meshheading:18257809-Inflammation,
pubmed-meshheading:18257809-Male,
pubmed-meshheading:18257809-Middle Aged,
pubmed-meshheading:18257809-Peritoneal Dialysis, Continuous Ambulatory,
pubmed-meshheading:18257809-Peritoneal Diseases,
pubmed-meshheading:18257809-S100 Proteins,
pubmed-meshheading:18257809-Sclerosis
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| pubmed:year |
2008
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| pubmed:articleTitle |
Plasma S100A12 concentrations in peritoneal dialysis patients and subclinical chronic inflammatory disease.
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| pubmed:affiliation |
Department of Medicine, Division of Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kyoto, Japan. uchiyama_kanda@houeikai.or.jp
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| pubmed:publicationType |
Journal Article
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