Linked Life Data

1825695

Source:http://linkedlifedata.com/resource/pubmed/id/1825695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-4-5
pubmed:abstractText
To determine the localization and functional significance of dystrophin, we studied various tissues from almost the entire body of control and mdx mice, and control rats, using polyclonal antibodies against dystrophin. We observed a dystrophin reaction in synaptic regions such as neuromuscular junctions, the equatorial region of intrafusal muscle fibers, the outer plexiform layer of the retina, the myoepithelial cell layer of salivary and sweat glands, tactile nerve endings, and neurons in the brain. These dystrophin-positive regions reportedly contain actin filaments as a common characteristic, which is compatible with the dystrophin cDNA sequence. Dystrophin was absent in these regions in mdx mice. These results suggest that dystrophin plays an important physiological and/or structural role in cell motility as a trigger for propagating contractile force in, for example, the conduction system, with some relationship between actin filaments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0148-639X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Dystrophin: localization and presumed function.
pubmed:affiliation
Department of Child Development, Kumamoto University Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't