Linked Life Data

18256547

Source:http://linkedlifedata.com/resource/pubmed/id/18256547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-4
pubmed:abstractText
In order to maintain genomic stability, cells must coordinate DNA replication such that every origin of replication fires once and only once per cell cycle. In addition, the order of replication and mitosis must be strictly controlled. To accomplish regulated origin firing, multicomponent pre-replicative complexes (pre-RCs) are assembled at origins of replication during G(1). The Cdc6 protein (Cdc6p) is one of the essential and highly regulated components of the pre-RC. In addition, Cdc6 appears to be important after DNA replication, specifically during mitosis. In this review, we discuss the role of Cdc6 in regulating cell cycle specific phosphorylation and a newly recognized role in dephosphorylation of substrates important for progression of mitosis. We present a model in which Cdc6 would couple the shift between the two mitotic oscillators contributing to the coordination of the order of mitosis with the initiation of DNA replication.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
597-601
pubmed:dateRevised
2008-9-23
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Linking mitosis with S-phase: Cdc6 at play.
pubmed:affiliation
Braun Laboratories 147-75, California Institute of Technology, Pasadena, California 91125, USA.
pubmed:publicationType
Journal Article, Review