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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-7
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pubmed:abstractText |
The efficacy and safety of artemether-lumefantrine for the treatment of malaria in nonimmune populations are not well defined. In this study, 165 nonimmune patients from Europe and non-malarious areas of Colombia with acute, uncomplicated falciparum malaria or mixed infection including P. falciparum were treated with the six-dose regimen of artemether-lumefantrine. The parasitologic cure rate at 28 days was 96.0% for the per protocol population (119/124 patients). Median times to parasite clearance and fever clearance were 41.5 and 36.8 hours, respectively. No patient had gametocytes after Day 7. Treatment was well tolerated; most adverse events were mild to moderate and seemed to be related to malaria. There were few serious adverse events, none of which were considered to be drug-related. No significant effects on ECG or laboratory parameters were observed. In conclusion, the six-dose regimen of artemether-lumefantrine was effective and well tolerated in the treatment of acute uncomplicated falciparum malaria in nonimmune patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9637
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pubmed:author |
pubmed-author:AndrianoKimK,
pubmed-author:BricaireFrancoisF,
pubmed-author:BurchardGerd-DieterGD,
pubmed-author:De PalaciosPatricia IbarraPI,
pubmed-author:GayFrederickF,
pubmed-author:GentonBlaiseB,
pubmed-author:HatzChristophC,
pubmed-author:LefèvreGilbertG,
pubmed-author:LoutanLouisL,
pubmed-author:NothdurftHans DieterHD,
pubmed-author:SotoJaimeJ,
pubmed-author:WeitzelThomasT,
pubmed-author:ZollerThomasT
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-7
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pubmed:meshHeading |
pubmed-meshheading:18256423-Acute Disease,
pubmed-meshheading:18256423-Adolescent,
pubmed-meshheading:18256423-Adult,
pubmed-meshheading:18256423-Aged,
pubmed-meshheading:18256423-Animals,
pubmed-meshheading:18256423-Antimalarials,
pubmed-meshheading:18256423-Artemisinins,
pubmed-meshheading:18256423-Drug Combinations,
pubmed-meshheading:18256423-Ethanolamines,
pubmed-meshheading:18256423-Female,
pubmed-meshheading:18256423-Fluorenes,
pubmed-meshheading:18256423-Humans,
pubmed-meshheading:18256423-Malaria, Falciparum,
pubmed-meshheading:18256423-Male,
pubmed-meshheading:18256423-Middle Aged,
pubmed-meshheading:18256423-Parasitemia,
pubmed-meshheading:18256423-Plasmodium falciparum,
pubmed-meshheading:18256423-Time Factors,
pubmed-meshheading:18256423-Travel,
pubmed-meshheading:18256423-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and pharmacokinetic study.
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pubmed:affiliation |
Medical Department, Swiss Tropical Institute, Basel, Switzerland. christoph.hatz@unibas.ch
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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