18255291

Source:http://linkedlifedata.com/resource/pubmed/id/18255291

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0208757, umls-concept:C0243192, umls-concept:C0268563, umls-concept:C1413555, umls-concept:C2698650
pubmed:issue	5
pubmed:dateCreated	2008-3-10
pubmed:abstractText	A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB2
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1464-3405
pubmed:author	pubmed-author:AmouzeghPatriciaP, pubmed-author:BrewerMark LML, pubmed-author:DymockBrian WBW, pubmed-author:EastStephen PSP, pubmed-author:EbnethAndreasA, pubmed-author:ErmannMonikaM, pubmed-author:GemkowMark JMJ, pubmed-author:JenkinsJames EJE, pubmed-author:KahrsAndreas FAF, pubmed-author:LöbbeSabineS, pubmed-author:MushiInnocent FIF, pubmed-author:Noya-MarinoBeatrizB, pubmed-author:O'SheaKathyK, pubmed-author:RietherDorisD, pubmed-author:ShihDaw-TsunDT, pubmed-author:TaylorMalcolm GMG, pubmed-author:ThomsonDavidD, pubmed-author:WalkerEdward RER
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1725-9
pubmed:meshHeading	pubmed-meshheading:18255291-Molecular Structure, pubmed-meshheading:18255291-Receptor, Cannabinoid, CB1, pubmed-meshheading:18255291-Receptor, Cannabinoid, CB2, pubmed-meshheading:18255291-Structure-Activity Relationship
pubmed:year	2008
pubmed:articleTitle	Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
pubmed:affiliation	Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom. monika.ermann@evotec.com
pubmed:publicationType	Journal Article