Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-7
pubmed:abstractText
Invasive aspergillosis (IA) is an increasingly common and often fatal fungal infection in children with haematological disorders. To describe the epidemiology, diagnosis, treatment and outcome of IA in children, retrospective review of the medical records of proven and probable IA between January 1986 and December 2000 was used. Twenty-four patients with IA were identified (10 proven and 14 probable) with a median age of 8.5 years. The incidence of IA was particularly high in acute myeloblastic leukaemia (5.35%) and leukaemia relapse (4%). Twenty-two patients presented with lung involvement. Broncho-alveolar lavage led to a diagnosis in 11 cases, but diagnosis was difficult and repeated invasive explorations were required. Antifungal therapy mainly consisted of amphotericin B. Eight patients underwent open-thorax surgery without any complication. Nine patients (37.5%) were cured of IA and three are still alive. The mortality was 87.5%. Three patients died of massive haemoptysis, including two before neutropenia recovery. Four patients presented with IA recurrence and three were cured again. Despite significant progress having been made in the treatment and diagnosis of IA, it is still a devastating complication in children with haematological disorders. New antifungal therapies and strategies are promising, but objective data are still lacking.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1439-0507
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-16
pubmed:meshHeading
pubmed-meshheading:18254746-Adolescent, pubmed-meshheading:18254746-Antifungal Agents, pubmed-meshheading:18254746-Aspergillosis, pubmed-meshheading:18254746-Child, pubmed-meshheading:18254746-Child, Preschool, pubmed-meshheading:18254746-Female, pubmed-meshheading:18254746-Hematologic Neoplasms, pubmed-meshheading:18254746-Hematology, pubmed-meshheading:18254746-Hospital Departments, pubmed-meshheading:18254746-Humans, pubmed-meshheading:18254746-Incidence, pubmed-meshheading:18254746-Infant, pubmed-meshheading:18254746-Leukemia, pubmed-meshheading:18254746-Leukemia, Myeloid, Acute, pubmed-meshheading:18254746-Lung Diseases, Fungal, pubmed-meshheading:18254746-Male, pubmed-meshheading:18254746-Pediatrics, pubmed-meshheading:18254746-Prognosis, pubmed-meshheading:18254746-Treatment Outcome
pubmed:year
2008
pubmed:articleTitle
Invasive aspergillosis in a paediatric haematology department: a 15-year review.
pubmed:affiliation
Department of Pediatric Hematology, Hôpital Debrousse, Lyon, France. ncrassard@ch-bourg01.fr
pubmed:publicationType
Journal Article