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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-2-6
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pubmed:abstractText |
1. The effect of 2-chloroadenosine (2CA), a P1 receptor agonist and beta,gamma-methylene ATP (betagamma mATP), a P2 receptor agonist, on the overflow of endogenous noradrenaline (NE) and the contractile response were examined in the electrically field-stimulated (EFS) (1 Hz) caudal artery obtained from Wistar-Kyoto (WKY) and SHR/NDmcr-cp (SHR-cp) rats. 2. Both 2CA and betagamma mATP reduced the EFS-evoked release of NE from the arteries of WKY. Also, 2CA significantly reduced the EFS-evoked contractile response in WKY, while it had no effect at all in SHR-cp. Betagamma mATP significantly reduced the EFS-evoked contractile response in both WKY and SHR-cp. Both 2CA and betagamma mATP did not affect the contractile response induced by NE at 1 micromol/L. 3. These results indicate that in the caudal arteries of SHR-cp, the P2 agonist but not the P1 agonist is functional in the prejunctional inhibitory regulation of adrenergic neurotransmission. This P1 dysfunction may play a role in the sympathetic hyperinnervation in metabolic syndrome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1440-1681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S60-1
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18254193-2-Chloroadenosine,
pubmed-meshheading:18254193-Adenosine Triphosphate,
pubmed-meshheading:18254193-Animals,
pubmed-meshheading:18254193-Arteries,
pubmed-meshheading:18254193-Electric Stimulation,
pubmed-meshheading:18254193-Male,
pubmed-meshheading:18254193-Metabolic Syndrome X,
pubmed-meshheading:18254193-Norepinephrine,
pubmed-meshheading:18254193-Purinergic P1 Receptor Agonists,
pubmed-meshheading:18254193-Purinergic P2 Receptor Agonists,
pubmed-meshheading:18254193-Rats,
pubmed-meshheading:18254193-Rats, Inbred SHR,
pubmed-meshheading:18254193-Rats, Inbred WKY,
pubmed-meshheading:18254193-Receptors, Purinergic P1,
pubmed-meshheading:18254193-Receptors, Purinergic P2,
pubmed-meshheading:18254193-Sympathetic Nervous System,
pubmed-meshheading:18254193-Synaptic Transmission,
pubmed-meshheading:18254193-Vasoconstriction
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pubmed:year |
2004
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pubmed:articleTitle |
Dysfunction of purinergic regulation of sympathetic neurotransmission in SHR/NDmcr-cp (SHR-cp) rat.
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pubmed:affiliation |
First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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