18253122

Source:http://linkedlifedata.com/resource/pubmed/id/18253122

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006142, umls-concept:C0026882, umls-concept:C0035647, umls-concept:C0441988, umls-concept:C1424448, umls-concept:C1742737, umls-concept:C2603343
pubmed:issue	4
pubmed:dateCreated	2008-2-19
pubmed:abstractText	The protein encoded by the CHEK2 gene is involved in cellular repair of DNA damage. The truncating mutation, CHEK21100delC, seems to increase the risk for breast cancer. We investigated whether the CHEK21100delC mutation carrier status increases the risk for asynchronous contralateral breast cancer (CBC) and whether it interacts with radiation therapy (RT) or chemotherapy in regard to CBC risk. The germline mutation frequency was assessed in 708 women with CBC and 1395 women with unilateral breast cancer (UBC) in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) Study whose first primary breast cancer was diagnosed before age 55 years and during 1985--1999. Seven women with CBC (1.0%) and 10 women with UBC (0.7%) were CHEK21100delC variant carriers (rate ratio (RR)=1.8, 95% confidence interval (CI)=0.6-5.4 for CBC vs UBC). Carriers who received RT for their first breast cancer, compared with non-carriers not treated with RT, had an RR of developing CBC of 2.6 (95% CI=0.8-8.7). We found no significant associations between the CHEK21100delC mutation and CBC overall or among those treated with RT. However, the sampling variability was such that modest increases in risk could not be excluded. Nonetheless, because this is a rare mutation, it is unlikely to explain a major fraction of CBC in the population.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/N01-PC-35139, http://linkedlifedata.com/resource/pubmed/grant/N01-PC-35142, http://linkedlifedata.com/resource/pubmed/grant/N01-PC35143, http://linkedlifedata.com/resource/pubmed/grant/N02-PC15105, http://linkedlifedata.com/resource/pubmed/grant/R01 CA097397, http://linkedlifedata.com/resource/pubmed/grant/R01 CA114236, http://linkedlifedata.com/resource/pubmed/grant/U01 CA083178, http://linkedlifedata.com/resource/pubmed/grant/U55/CCR921930-02
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-11053450, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-11967536, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-12094328, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-14618615, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-14678969, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-14997059, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15084244, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15122511, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15361851, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15466005, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15472904, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15535844, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-15803365, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16337852, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16492927, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16758118, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16830057, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16880452, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-16998506, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-17132695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-17428320, http://linkedlifedata.com/resource/pubmed/commentcorrection/18253122-18182601
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370635
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/checkpoint kinase 2
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0007-0920
pubmed:author	pubmed-author:AnderssonMM, pubmed-author:Børresen-DaleA-LAL, pubmed-author:BernsteinJ LJL, pubmed-author:BernsteinLL, pubmed-author:BertelsenLL, pubmed-author:BoiceJ DJDJr, pubmed-author:CapanuMM, pubmed-author:ChristensenJJ, pubmed-author:ConcannonPP, pubmed-author:DahlCC, pubmed-author:GuldbergPP, pubmed-author:HaginR ARA, pubmed-author:LangholzBB, pubmed-author:LynchC FCF, pubmed-author:MaloneK EKE, pubmed-author:MellemkjaerLL, pubmed-author:OlsenJ HJH, pubmed-author:StovallMM, pubmed-author:ThomasD CDC, pubmed-author:WECARE Study Collaborative Group
pubmed:issnType	Print
pubmed:day	26
pubmed:volume	98
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	728-33
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:18253122-Breast Neoplasms, pubmed-meshheading:18253122-Case-Control Studies, pubmed-meshheading:18253122-Female, pubmed-meshheading:18253122-Genotype, pubmed-meshheading:18253122-Germ-Line Mutation, pubmed-meshheading:18253122-Humans, pubmed-meshheading:18253122-Middle Aged, pubmed-meshheading:18253122-Protein-Serine-Threonine Kinases, pubmed-meshheading:18253122-Risk Factors, pubmed-meshheading:18253122-SEER Program
pubmed:year	2008
pubmed:articleTitle	Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study.
pubmed:affiliation	Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. lene@cancer.dk
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study, Research Support, N.I.H., Extramural