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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-3-8
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pubmed:abstractText |
We have examined the effects of a stromal cell-derived cytokine designated interleukin 11 (IL-11) on the proliferation of murine hemopoietic progenitors in methylcellulose culture. COS cell-conditioned medium containing IL-11 supported formation of granulocyte/macrophage colonies and a small number of multilineage colonies including blast cell colonies in cultures of marrow cells from normal mice. When tested with marrow cells harvested 2 days after injection of 5-fluorouracil at 150 mg/kg, IL-11 enhanced interleukin 3-dependent colony formation, whereas IL-11 alone supported only scant colony formation. Serial observations (mapping studies) of cultures of post-5-fluorouracil spleen cells indicated that the mechanism of the synergistic effect of IL-11 is to shorten the dormant period of stem cells, an effect very similar to that of interleukin 6. When pooled blast cells were plated into medium containing IL-11 and erythropoietin, only macrophage colonies were observed. Thus, IL-11 can directly support the proliferation of committed macrophage progenitors and, and like interleukin 6 and granulocyte colony-stimulating factor, act synergistically with interleukin 3 to shorten the Go period of early progenitors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-1692490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2145578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2453060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2473791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2698877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2786878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2788282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2788464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-2813429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-3258892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-3264195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-3501121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-3930522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-481601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-6654987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-6954527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-7096452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1825140-719177
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1825140-Animals,
pubmed-meshheading:1825140-Bone Marrow Cells,
pubmed-meshheading:1825140-Cell Differentiation,
pubmed-meshheading:1825140-Cell Line,
pubmed-meshheading:1825140-Cells, Cultured,
pubmed-meshheading:1825140-Drug Synergism,
pubmed-meshheading:1825140-Female,
pubmed-meshheading:1825140-Fluorouracil,
pubmed-meshheading:1825140-Hematopoiesis,
pubmed-meshheading:1825140-Hematopoietic Stem Cells,
pubmed-meshheading:1825140-Interleukin-11,
pubmed-meshheading:1825140-Interleukin-3,
pubmed-meshheading:1825140-Interleukin-6,
pubmed-meshheading:1825140-Interleukins,
pubmed-meshheading:1825140-Kinetics,
pubmed-meshheading:1825140-Mice,
pubmed-meshheading:1825140-Mice, Inbred Strains,
pubmed-meshheading:1825140-Recombinant Proteins,
pubmed-meshheading:1825140-Spleen,
pubmed-meshheading:1825140-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.
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pubmed:affiliation |
Department of Medicine, Medical University of South Carolina, Charleston.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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