|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0105770,
umls-concept:C0162493,
umls-concept:C0185117,
umls-concept:C0334227,
umls-concept:C0345904,
umls-concept:C1099354,
umls-concept:C1412325,
umls-concept:C2911684
|
|
pubmed:issue |
79
|
|
pubmed:dateCreated |
2008-2-6
|
|
pubmed:abstractText |
It has been proved that changes in the Wnt/beta-catenin pathway lead to hepatocarcinogenesis and the AKR1C2 gene may contribute to the occurrence, advancement and invasiveness of liver cancer. The purpose of this study is to investigate AKR1C2 small interfering RNA (siRNA) influence on beta-catenin expression and transcriptional activation in the human liver cancer cell line QGY7701.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0172-6390
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2088-91
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18251165-Cell Line, Tumor,
pubmed-meshheading:18251165-Down-Regulation,
pubmed-meshheading:18251165-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18251165-Humans,
pubmed-meshheading:18251165-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:18251165-RNA, Small Interfering,
pubmed-meshheading:18251165-Signal Transduction,
pubmed-meshheading:18251165-T Cell Transcription Factor 1,
pubmed-meshheading:18251165-Transcriptional Activation,
pubmed-meshheading:18251165-beta Catenin
|
|
pubmed:articleTitle |
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
|
|
pubmed:affiliation |
Tongji University School of Life Science and Technology, Shanghai, 200092, People's Republic of China. ludondon88@163.com
|
|
pubmed:publicationType |
Journal Article
|
