Linked Life Data

18250492

Source:http://linkedlifedata.com/resource/pubmed/id/18250492

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
153
pubmed:dateCreated
2008-2-5
pubmed:abstractText
The aim of our investigation was to study the impact of the decrease of diurnal doses of insulin on main metabolic and anthropometric parameters in patients with DM2, who underwent the high diurnal doses of insulin. 36 patient with DM2 (mean age - 49,1+/-8,7 years) on high doses of insulin have been investigated. On the first stage the parameters of carbohydrate metabolism, HOMA-indices, parameters of lipid metabolism and blood pressure have been determined. I group consisted of 20 patients with decreased diurnal doses of insulin (from 65,6+/-19,3 units to 22,2+/-18,7 units), and II group - 16 patients with decreased diurnal doses of insulin (from 61,0+/-21,1 units to 45,3+/-7,5 units) and addition of metformin. After 6 months of treatment all parameters have been also determined. Fasting and postprandial glycemia and HbA(1C) levels were significantly decreased in both groups. C-peptide levels did not significantly change in I group. HOMA-%B and HOMA-%S indices significantly increased in both group, but the parameter of insulin resistance - HOMA-IR was significantly decreased only in II group. The improvement of dyslipidemia, hypertension and obesity was more expressed in II group. The positive changes in main metabolic and anthropometric parameters were more expressed in patients treatment tactics of whom consisted of insulin-sensitizing preparations.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1512-0112
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:pagination
28-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[The impact of the decrease of diurnal doses of insulin on main metabolic and anthropometric parameters in patients with DM2].
pubmed:publicationType
Journal Article, English Abstract