Source:http://linkedlifedata.com/resource/pubmed/id/18250457
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-2-5
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pubmed:abstractText |
Type III IFNs (IFN-lambda/IL-28/29) are cytokines with type I IFN-like antiviral activities, which remain poorly characterized. We herein show that most cell types expressed both types I and III IFNs after TLR stimulation or virus infection, whereas the ability of cells to respond to IFN-lambda was restricted to a narrow subset of cells, including plasmacytoid dendritic cells and epithelial cells. To examine the role of type III IFN in antiviral defense, we generated IL-28Ralpha-deficient mice. These mice were indistinguishable from wild-type mice with respect to clearance of a panel of different viruses, whereas mice lacking the type I IFN receptor (IFNAR(-/-)) were significantly impaired. However, the strong antiviral activity evoked by treatment of mice with TLR3 or TLR9 agonists was significantly reduced in both IL-28RA(-/-) and IFNAR(-/-) mice. The type I IFN receptor system has been shown to mediate positive feedback on IFN-alphabeta expression, and we found that the type I IFN receptor system also mediates positive feedback on IFN-lambda expression, whereas IL-28Ralpha signaling does not provide feedback on either type I or type III IFN expression in vivo. Finally, using bone-marrow chimeric mice we showed that TLR-activated antiviral defense requires expression of IL-28Ralpha only on nonhemopoietic cells. In this compartment, epithelial cells responded to IFN-lambda and directly restricted virus replication. Our data suggest type III IFN to target a specific subset of cells and to contribute to the antiviral response evoked by TLRs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/interferon-lambda protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin 28alpha receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AnkNinaN,
pubmed-author:BartholdyChristinaC,
pubmed-author:ChenZhiZ,
pubmed-author:Dagnaes-HansenFrederikF,
pubmed-author:HartmannRuneR,
pubmed-author:HaugenHaraldH,
pubmed-author:IversenMarie BMB,
pubmed-author:JensenUffe BUB,
pubmed-author:KlucherKevinK,
pubmed-author:PaludanSøren RSR,
pubmed-author:StaeheliPeterP,
pubmed-author:ThomsenAllan RAR
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2474-85
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pubmed:meshHeading |
pubmed-meshheading:18250457-Animals,
pubmed-meshheading:18250457-Antiviral Agents,
pubmed-meshheading:18250457-Crosses, Genetic,
pubmed-meshheading:18250457-Cytokines,
pubmed-meshheading:18250457-Epithelial Cells,
pubmed-meshheading:18250457-Female,
pubmed-meshheading:18250457-Hematopoietic Stem Cells,
pubmed-meshheading:18250457-Herpes Genitalis,
pubmed-meshheading:18250457-Herpesvirus 2, Human,
pubmed-meshheading:18250457-Ligands,
pubmed-meshheading:18250457-Mice,
pubmed-meshheading:18250457-Mice, Inbred C57BL,
pubmed-meshheading:18250457-Mice, Knockout,
pubmed-meshheading:18250457-Mice, Mutant Strains,
pubmed-meshheading:18250457-Radiation Chimera,
pubmed-meshheading:18250457-Receptors, Cytokine,
pubmed-meshheading:18250457-Toll-Like Receptors
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pubmed:year |
2008
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pubmed:articleTitle |
An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.
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pubmed:affiliation |
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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