Linked Life Data

18250446

Source:http://linkedlifedata.com/resource/pubmed/id/18250446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-2-5
pubmed:abstractText
During human early pregnancy, fetus-derived trophoblasts come into direct contact with maternal immune cells at the maternofetal interface. At sites of placental attachment, invasive extravillous trophoblasts encounter decidual leukocytes (DLC) that accumulate within the decidua. Because we first found chemokine CXCL16 was highly expressed in and secreted by the first-trimester human trophoblasts previously, in this study we tested the hypothesis of whether the fetal trophoblasts can direct migration of maternal T lymphocyte and monocytes into decidua by secreting CXCL16. We analyzed the transcription and translation of CXCL16 in the isolated first-trimester human trophoblast, and examined the kinetic secretion of CXCL16 in the supernatant of the primary-cultured trophoblasts. We demonstrated that the sole receptor of CXCL16, CXCR6, is preferentially expressed in T lymphocytes, NKT cells, and monocytes, hardly expressed in two subsets of NK cells from either the peripheral blood or decidua. We further demonstrated the chemotactic activity of CXCL16 in the supernatant of the primary trophoblast on the peripheral mononuclear cells and DLC. Moreover, the CXCL16/CXCR6 interaction is involved in the migration of the peripheral T lymphocytes, gammadelta T cells, and monocytes, but not NKT cells. In addition, the trophoblast-conditioned medium could enrich PBMC subsets selectively to constitute a leukocyte population with similar composition to that of DLC, which suggests that the fetus-derived trophoblasts can attract T cells, gammadelta T cells, and monocytes by producing CXCL16 and interaction with CXCR6 on these cells, leading to forming a specialized immune milieu at the maternofetal interface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2367-75
pubmed:meshHeading
pubmed-meshheading:18250446-Cell Differentiation, pubmed-meshheading:18250446-Cell Separation, pubmed-meshheading:18250446-Cells, Cultured, pubmed-meshheading:18250446-Chemokines, CXC, pubmed-meshheading:18250446-Chemotaxis, Leukocyte, pubmed-meshheading:18250446-Culture Media, Conditioned, pubmed-meshheading:18250446-Decidua, pubmed-meshheading:18250446-Female, pubmed-meshheading:18250446-Humans, pubmed-meshheading:18250446-Immunohistochemistry, pubmed-meshheading:18250446-Maternal-Fetal Exchange, pubmed-meshheading:18250446-Monocytes, pubmed-meshheading:18250446-Pregnancy, pubmed-meshheading:18250446-Pregnancy Trimester, First, pubmed-meshheading:18250446-Receptors, Chemokine, pubmed-meshheading:18250446-Receptors, Scavenger, pubmed-meshheading:18250446-Receptors, Virus, pubmed-meshheading:18250446-T-Lymphocyte Subsets, pubmed-meshheading:18250446-Trophoblasts
pubmed:year
2008
pubmed:articleTitle
Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6 in the first-trimester pregnancy.
pubmed:affiliation
Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't