Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-15
pubmed:abstractText
The receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an inhibitory function in signaling and proliferation in nonhematopoietic cells. However, its role in the immune system has not been thoroughly studied. Our analysis of CD148 loss-of-function mice showed that CD148 has a positive regulatory function in B cells and macrophages, similar to the role of CD45 as a positive regulator of Src family kinases (SFKs). Analysis of CD148 and CD45 doubly deficient B cells and macrophages revealed hyperphosphorylation of the C-terminal inhibitory tyrosine of SFKs accompanied by substantial alterations in B and myeloid lineage development and defective immunoreceptor signaling. Because these findings suggest the C-terminal tyrosine of SFKs is a common substrate for both CD148 and CD45 phosphatases and imply a level of redundancy not previously appreciated, a reassessment of the function of CD45 in the B and myeloid lineages based on prior data from the CD45-deficient mouse is warranted.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10233842, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10508267, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10684859, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10700239, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10781611, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10821867, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10933588, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-10933592, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11094075, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11145714, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11201744, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11259588, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11602179, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-11672542, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12089527, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12414720, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12475979, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12563261, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12588999, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12776199, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-12833140, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-15231692, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-15294945, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-15735685, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-16000320, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-16356861, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-16378097, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-16682945, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-1672451, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-16792508, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-3352600, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-3463975, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-7509083, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-7584145, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-7585947, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8137818, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8334701, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8551241, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8566034, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8666928, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8797598, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-8940015, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9197241, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9205113, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9314552, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9419213, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9434895, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249142-9874568
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1074-7613
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-96
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
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