Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-2-11
pubmed:abstractText
Cerebral blood volume (CBV)-weighted endogenous functional contrast can be obtained by the vascular space occupancy (VASO) technique. VASO relies on nonselective inversion for nulling blood signals, but the implementation of VASO at magnetic fields higher than 3 T is difficult due to converging T(1) values of tissue and blood water and a stronger counteracting blood oxygen level-dependent (BOLD) effect. To improve functional CBV sensitivity, we proposed to use VASO with slab-selective inversion (SI-VASO). Computer simulations showed that the SI-VASO approach significantly increases functional sensitivity compared to the original VASO in a stronger magnetic field with a shorter repetition time. To examine layer-dependent specificity, SI-VASO and spin-echo BOLD (SE-BOLD) functional magnetic resonance imaging (fMRI) experiments were performed on isoflurane-anesthetized cats during visual stimulation at 9.4 T. Unlike simultaneously acquired SE-BOLD signal, the SI-VASO signal peaked at 0.9 mm from the surface of the cortex and was localized to the middle cortical layer. The full-width at half maximal response across the cortex was narrower for SI-VASO than for SE-BOLD (1.7 mm vs. 2.5 mm, respectively), suggesting that SI-VASO is better localized to neuronally active sites than SE-BOLD fMRI. The magnitude of the SI-VASO change in the middle cortex was -1.45% with our experimental parameters, corresponding to a relative CBV change of approximately 8% when baseline CBV was assumed to be 5% in a two-compartment model. The signal response profile across the cortex, the calculated CBV change, and the time course of SI-VASO fMRI were similar to those of previously obtained CBV-weighted fMRI with contrast agent in the same animal model, suggesting that SI-VASO measures predominantly functional CBV responses.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-10542351, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-10542354, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-11241702, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-11333371, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-11719199, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-11740891, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-12030817, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-12601170, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-12695101, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-12796714, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-12876702, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15004793, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15241184, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15508149, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15562477, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15588591, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15799063, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-15923128, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16194614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16222242, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16278086, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16414284, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16677944, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-16700023, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-17051530, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-17075857, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-17108155, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-1948051, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-8744018, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-9543418, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-9543424, http://linkedlifedata.com/resource/pubmed/commentcorrection/18249010-9840828
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-67
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Improved cortical-layer specificity of vascular space occupancy fMRI with slab inversion relative to spin-echo BOLD at 9.4 T.
pubmed:affiliation
Department of Radiology, University of Pittsburgh, 3025 East Carson Street, University of Pittsburgh, Pittsburgh, PA 15203, USA. taj6@pitt.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural