Linked Life Data

18249009

Source:http://linkedlifedata.com/resource/pubmed/id/18249009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-2-11
pubmed:abstractText
Hippocampal surface structure was assessed at twice 2 years apart in 26 nondemented subjects (CDR 0), in 18 subjects with early dementia of Alzheimer type (DAT, CDR 0.5), and in 9 subjects who converted from the nondemented (CDR 0) to the demented (CDR 0.5) state using magnetic resonance (MR) imaging. We used parallel transport in diffeomorphisms under the large deformation diffeomorphic metric mapping framework to translate within-subject deformation of the hippocampal surface as represented in the MR images between the two time points in a global template coordinate system. We then performed hypothesis testing on the longitudinal variation of hippocampal shape in the global template. Both subjects with early DAT and converters showed greater rates of hippocampal deformation across time than nondemented controls within every subfield of the hippocampus. In a random field analysis, inward surface deformation across time occurred in a non-uniform manner across the hippocampal surface in subjects with early DAT relative to the nondemented controls. Also, compared to the controls, the lateral aspect of the left hippocampal tail showed inward surface deformation in the converters. Using surface deformation patterns as features in a linear discriminant analysis, we were able to respectively distinguish converters and patients with early DAT from healthy nondemented controls at classification rates of 0.77 and 0.87, which were obtained in the same training set using the leave-one-out cross validation approach.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/P01 AG 03991, http://linkedlifedata.com/resource/pubmed/grant/P01 AG003991-250013, http://linkedlifedata.com/resource/pubmed/grant/P41 RR 15241, http://linkedlifedata.com/resource/pubmed/grant/P41 RR015241-060004, http://linkedlifedata.com/resource/pubmed/grant/P50 AG 05681, http://linkedlifedata.com/resource/pubmed/grant/P50 AG005681-25, http://linkedlifedata.com/resource/pubmed/grant/P50 MH 071616, http://linkedlifedata.com/resource/pubmed/grant/P50 MH071616-050001, http://linkedlifedata.com/resource/pubmed/grant/R01 AG 025824, http://linkedlifedata.com/resource/pubmed/grant/R01 AG025824-04, http://linkedlifedata.com/resource/pubmed/grant/R01 EB 00975, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000975-05A2, http://linkedlifedata.com/resource/pubmed/grant/R01 MH 064838, http://linkedlifedata.com/resource/pubmed/grant/R01 MH060883-09, http://linkedlifedata.com/resource/pubmed/grant/R01 O60883
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-76
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type.
pubmed:affiliation
Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore, Singapore. bieqa@nus.edu.sg
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural