Linked Life Data

18249004

Source:http://linkedlifedata.com/resource/pubmed/id/18249004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-4-28
pubmed:abstractText
The nervous system is a superordinate organ in the body that controls the function of virtually all other organs and tissues. In the past, the role of the nervous system in cancer development and progression has largely been ascribed to an immunosuppressive function, which saps the immune system's ability to respond to a tumor. However, it is now clear that direct interactions of tumor cells with nerve cells occur, too. We herein provide arguments for the hypothesis that tumors initiate their own innervation by the release of neurotrophic factors including the nerve growth factor, the brain-derived growth factor, and the vascular endothelial growth factor. By this process, which we have termed neoneurogenesis, the tumor cells get in close contact to the nerve cells, forming a neuro-neoplastic synapse. Through these synapses, neurotransmitters are directly supplied to the tumors, which has impact on tumor growth and metastasis formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1096-3650
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The cancer's nervous tooth: Considering the neuronal crosstalk within tumors.
pubmed:affiliation
Institute of Immunology, Witten/Herdecke University, Stockumer Street 10, 58448 Witten, Germany. entschladen@uni-wh.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't