Source:http://linkedlifedata.com/resource/pubmed/id/18248814
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-2-5
|
| pubmed:abstractText |
Imidazo[4,5-c]quinoline derivatives have been discovered and developed as potent and effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway to lead to clinical development candidates. The SAR data of representative examples of this compound class and their biological profiling in cellular and in vivo settings are presented and discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1027-30
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:18248814-Animals,
pubmed-meshheading:18248814-Imidazoles,
pubmed-meshheading:18248814-Mice,
pubmed-meshheading:18248814-Mice, Nude,
pubmed-meshheading:18248814-Molecular Structure,
pubmed-meshheading:18248814-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18248814-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18248814-Quinolines,
pubmed-meshheading:18248814-Structure-Activity Relationship
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway.
|
| pubmed:affiliation |
Novartis Institute for BioMedical Research, Oncology Drug Discovery, Klybeckstrasse 141, Postfach, CH-4002 Basel, Switzerland. frederic.stauffer@novartis.com
|
| pubmed:publicationType |
Journal Article
|