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pubmed:abstractText |
The indispensability of certain genes in an organism is important for studies of microorganism physiology, antibiotic targeting, and the engineering of minimal genomes. Time and resource intensive genome-wide experimental screens can be conducted to determine which genes are likely essential. For metabolic genes, a reconstructed metabolic network can be used to predict which genes are likely essential. The success rate of these predictions is less than desirable, especially with regard to comprehensively locating essential genes.
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pubmed:affiliation |
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive 0412, La Jolla, CA 92093, USA. sabecker@ucsd.edu
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