|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-5-5
|
|
pubmed:abstractText |
The dentate gyrus (DG) is a gateway that regulates seizure activity in the hippocampus. We investigated the site of action of lamotrigine (LTG), an effective anticonvulsant, in the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartic acid (NMDA) receptor-mediated excitatory synaptic transmission on DG.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0013-9580
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
888-97
|
|
pubmed:meshHeading |
pubmed-meshheading:18248444-Animals,
pubmed-meshheading:18248444-Anticonvulsants,
pubmed-meshheading:18248444-Dentate Gyrus,
pubmed-meshheading:18248444-Disease Models, Animal,
pubmed-meshheading:18248444-Epilepsy,
pubmed-meshheading:18248444-Excitatory Postsynaptic Potentials,
pubmed-meshheading:18248444-Glutamates,
pubmed-meshheading:18248444-Male,
pubmed-meshheading:18248444-Rats,
pubmed-meshheading:18248444-Rats, Wistar,
pubmed-meshheading:18248444-Receptors, AMPA,
pubmed-meshheading:18248444-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:18248444-Triazines,
pubmed-meshheading:18248444-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus.
|
|
pubmed:affiliation |
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
