|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013216,
umls-concept:C0040083,
umls-concept:C0040085,
umls-concept:C0058126,
umls-concept:C0220901,
umls-concept:C0237881,
umls-concept:C0332293,
umls-concept:C0750502,
umls-concept:C1171362,
umls-concept:C1516213,
umls-concept:C1527249
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pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-4-29
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|
pubmed:abstractText |
Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
May
|
|
pubmed:issn |
1569-8041
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|
pubmed:author |
pubmed-author:BOSS,
pubmed-author:DiasioR BRB,
pubmed-author:FoxJ CJC,
pubmed-author:IacopettaBB,
pubmed-author:JosephDD,
pubmed-author:LuS CSC,
pubmed-author:Salto-TellezMM,
pubmed-author:ShahNN,
pubmed-author:SoongRR,
pubmed-author:TaiB CBC,
pubmed-author:XunLinL,
pubmed-author:ZepsNN
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|
pubmed:issnType |
Electronic
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pubmed:volume |
19
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
915-9
|
|
pubmed:dateRevised |
2011-9-26
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|
pubmed:meshHeading |
pubmed-meshheading:18245778-Adenocarcinoma,
pubmed-meshheading:18245778-Aged,
pubmed-meshheading:18245778-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18245778-Chemotherapy, Adjuvant,
pubmed-meshheading:18245778-Colorectal Neoplasms,
pubmed-meshheading:18245778-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:18245778-Drug Resistance, Neoplasm,
pubmed-meshheading:18245778-Female,
pubmed-meshheading:18245778-Fluorouracil,
pubmed-meshheading:18245778-Follow-Up Studies,
pubmed-meshheading:18245778-Humans,
pubmed-meshheading:18245778-Leucovorin,
pubmed-meshheading:18245778-Male,
pubmed-meshheading:18245778-Middle Aged,
pubmed-meshheading:18245778-Neoplasm Proteins,
pubmed-meshheading:18245778-Neoplasm Staging,
pubmed-meshheading:18245778-Prognosis,
pubmed-meshheading:18245778-Survival Analysis,
pubmed-meshheading:18245778-Thymidine Phosphorylase,
pubmed-meshheading:18245778-Thymidylate Synthase
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
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|
pubmed:affiliation |
Oncology Research Institute, National University of Singapore, Singapore. nmirs@nus.edu.sg
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
