|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2008-2-4
|
|
pubmed:abstractText |
We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AlsayedYazanY,
pubmed-author:AndersonJudyJ,
pubmed-author:AndersonKenneth CKC,
pubmed-author:GhobrialIrene MIM,
pubmed-author:HatjiharissiEvdoxiaE,
pubmed-author:HideshimaTeruT,
pubmed-author:HustonAlissaA,
pubmed-author:JiaXiaoyingX,
pubmed-author:LeleuXavierX,
pubmed-author:MoreauAnne-SophieAS,
pubmed-author:MunshiNikhilN,
pubmed-author:NgoHai THT,
pubmed-author:RichardsonPaulP,
pubmed-author:RoccaroAldoA,
pubmed-author:RoodmanDavid GDG,
pubmed-author:RunnelsJudithJ,
pubmed-author:SportelliPeterP,
pubmed-author:TaiYu-TsuYT,
pubmed-author:ValletSoniaS
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
865-74
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18245550-Benzoquinones,
pubmed-meshheading:18245550-Bone Marrow,
pubmed-meshheading:18245550-Cell Cycle,
pubmed-meshheading:18245550-Cell Division,
pubmed-meshheading:18245550-Cell Line, Tumor,
pubmed-meshheading:18245550-Cell Survival,
pubmed-meshheading:18245550-DNA Replication,
pubmed-meshheading:18245550-Flow Cytometry,
pubmed-meshheading:18245550-HSP90 Heat-Shock Proteins,
pubmed-meshheading:18245550-Humans,
pubmed-meshheading:18245550-Lactams, Macrocyclic,
pubmed-meshheading:18245550-Multiple Myeloma,
pubmed-meshheading:18245550-Phosphorylcholine,
pubmed-meshheading:18245550-Proto-Oncogene Proteins c-akt
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
|
|
pubmed:affiliation |
James P. Wilmot Cancer Center, University of Rochester, Rochester, New York, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
