Linked Life Data

1824539

Source:http://linkedlifedata.com/resource/pubmed/id/1824539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1992-10-22
pubmed:abstractText
The effect of TRH and its analogon "RGH 2022" (Gedeon Richter, Budapest) on parameters of open field (OF) behaviour, wheel running (WR) and sleep-wakefulness cycles was recorded after intraperitoneal injections of the drugs in two dosages, 1 microgram/kg and 10 micrograms/kg, and compared with the control group. The lower TRH dose enhanced exploratory activity in the OF to 130%, WR to 150%, but reduced the entrance to central fields in the OF to 50%. The higher TRH dose reduced the locomotor activity in the OF to 53% and the entrance to central fields to 15% but enhanced the exploratory index to 190%. The analogon RGH 2022 had less effects in its lower dose and mimicked the TRH effect in its higher dose. The amount of all waking states increased after TRH to 120%. Single periods of relaxed wakefulness and sleep phases (slow wave sleep and paradoxical sleep) were 15-20% prolonged after 10 micrograms/kg TRH on account of phase frequency. There was, however, a maximum of sleep phase frequency and duration between the 35th and 55th min after TRH application.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1217-24
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Systemically applied thyrotropin-releasing hormone (TRH) modifies spontaneous behaviour of rats.
pubmed:affiliation
Paul Flechsig Institute for Brain Research, Department of Neurophysiology, University of Leipzig.
pubmed:publicationType
Journal Article