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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-3-10
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pubmed:abstractText |
A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNa(v)1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10mg/kg.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AbbadieCatherineC,
pubmed-author:DeanBrianB,
pubmed-author:DuffyJoseph LJL,
pubmed-author:FelixJohn PJP,
pubmed-author:GarciaMaria LML,
pubmed-author:HoytScott BSB,
pubmed-author:JochnowitzNinaN,
pubmed-author:KaczorowskiGregory JGJ,
pubmed-author:KaranamBindhu VBV,
pubmed-author:LiXiaohuaX,
pubmed-author:LondonClareC,
pubmed-author:LyonsKathryn AKA,
pubmed-author:MartinWilliam JWJ,
pubmed-author:McGowanErinE,
pubmed-author:ParsonsWilliam HWH,
pubmed-author:PriestBirgit TBT,
pubmed-author:SmithMcHardy MMM,
pubmed-author:Tschirret-GuthRichardR,
pubmed-author:WarrenVivien AVA,
pubmed-author:WilliamsBrande SBS
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1696-701
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Imidazopyridines: a novel class of hNav1.7 channel blockers.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. clare_london@merck.com
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pubmed:publicationType |
Journal Article
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