| pubmed-article:18243555 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C0233794 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C0232970 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C1412727 | lld:lifeskim |
| pubmed-article:18243555 | lifeskim:mentions | umls-concept:C1707919 | lld:lifeskim |
| pubmed-article:18243555 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18243555 | pubmed:dateCreated | 2008-2-29 | lld:pubmed |
| pubmed-article:18243555 | pubmed:abstractText | Ovarian hormone decline after menopause may influence cognitive performance and increase the risk for Alzheimer's disease (AD) in women. We have recently demonstrated that a combination of ovariectomy and chronic stress (OVX/stress) causes hippocampus-associated cognitive dysfunction in mice. In this study, we examined whether OVX/stress could affect the levels of AD-related molecules in the mouse hippocampus. Female ICR mice were ovariectomized or sham-operated, and then randomly divided into a daily restraint stress (21 days, 6 h/day) or non-stress group. Although OVX or stress alone did not affect beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1) activity, OVX/stress increased activity in hippocampal CA1 and CA3 regions, compared with other groups. In contrast, OVX/stress did not affect gamma-secretase activity, Abeta(1-40), and phosphorylated-tau levels in the hippocampus. These findings suggest that a stressful life after menopause can influence the levels of AD-related molecules and that BACE1 is the most sensitive molecule for such a situation. | lld:pubmed |
| pubmed-article:18243555 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18243555 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18243555 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18243555 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18243555 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18243555 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18243555 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18243555 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18243555 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:YamadaKiyofum... | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:YoshidaShiger... | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:InoueMasakiM | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:KoikeKojiK | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:TakumaKazuhir... | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:MizoguchiHiro... | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:IbiDaisukeD | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:HimenoYukikoY | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:FukuzakiEmiko... | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:FunatsuYokoY | lld:pubmed |
| pubmed-article:18243555 | pubmed:author | pubmed-author:KitaharaYukoY | lld:pubmed |
| pubmed-article:18243555 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18243555 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:18243555 | pubmed:volume | 433 | lld:pubmed |
| pubmed-article:18243555 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18243555 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18243555 | pubmed:pagination | 141-5 | lld:pubmed |
| pubmed-article:18243555 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
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| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:meshHeading | pubmed-meshheading:18243555... | lld:pubmed |
| pubmed-article:18243555 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18243555 | pubmed:articleTitle | Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. | lld:pubmed |
| pubmed-article:18243555 | pubmed:affiliation | Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. | lld:pubmed |
| pubmed-article:18243555 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18243555 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18243555 | lld:pubmed |
