Source:http://linkedlifedata.com/resource/pubmed/id/18243555
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-2-29
|
| pubmed:abstractText |
Ovarian hormone decline after menopause may influence cognitive performance and increase the risk for Alzheimer's disease (AD) in women. We have recently demonstrated that a combination of ovariectomy and chronic stress (OVX/stress) causes hippocampus-associated cognitive dysfunction in mice. In this study, we examined whether OVX/stress could affect the levels of AD-related molecules in the mouse hippocampus. Female ICR mice were ovariectomized or sham-operated, and then randomly divided into a daily restraint stress (21 days, 6 h/day) or non-stress group. Although OVX or stress alone did not affect beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1) activity, OVX/stress increased activity in hippocampal CA1 and CA3 regions, compared with other groups. In contrast, OVX/stress did not affect gamma-secretase activity, Abeta(1-40), and phosphorylated-tau levels in the hippocampus. These findings suggest that a stressful life after menopause can influence the levels of AD-related molecules and that BACE1 is the most sensitive molecule for such a situation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0304-3940
|
| pubmed:author |
pubmed-author:FukuzakiEmikoE,
pubmed-author:FunatsuYokoY,
pubmed-author:HimenoYukikoY,
pubmed-author:IbiDaisukeD,
pubmed-author:InoueMasakiM,
pubmed-author:KitaharaYukoY,
pubmed-author:KoikeKojiK,
pubmed-author:MizoguchiHiroyukiH,
pubmed-author:TakumaKazuhiroK,
pubmed-author:YamadaKiyofumiK,
pubmed-author:YoshidaShigeruS
|
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
433
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
141-5
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:18243555-Amyloid Precursor Protein Secretases,
pubmed-meshheading:18243555-Analysis of Variance,
pubmed-meshheading:18243555-Animals,
pubmed-meshheading:18243555-Aspartic Acid Endopeptidases,
pubmed-meshheading:18243555-Disease Models, Animal,
pubmed-meshheading:18243555-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18243555-Female,
pubmed-meshheading:18243555-Gene Expression Regulation,
pubmed-meshheading:18243555-Hippocampus,
pubmed-meshheading:18243555-Memory Disorders,
pubmed-meshheading:18243555-Mice,
pubmed-meshheading:18243555-Mice, Inbred ICR,
pubmed-meshheading:18243555-Ovariectomy,
pubmed-meshheading:18243555-Postmenopause,
pubmed-meshheading:18243555-Restraint, Physical,
pubmed-meshheading:18243555-Stress, Psychological,
pubmed-meshheading:18243555-Time Factors
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits.
|
| pubmed:affiliation |
Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|