Linked Life Data

18241873

Source:http://linkedlifedata.com/resource/pubmed/id/18241873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-2-18
pubmed:abstractText
In the present study the photocatalytic degradation of bezafibrate (BZF), a lipid regulator agent, has been investigated using TiO(2) suspensions and simulated solar light. The study focus on the identification of degradation products (DPs) using powerful analytical techniques such as liquid chromatography time of flight mass spectrometry (LC-TOF-MS), gas chromatography mass spectrometry (GC-MS), and high-performance liquid chromatography with diode-array detection (HPLC-DAD). Each technique provided complementary information that enabled the identification of 21 DPs. Accurate mass measurements obtained by LC-TOF-MS provided the elucidation of 17 DPs. Mass errors lower than 2mDa, allowed the assignment of empirical formula for the mayor DPs to be determined confidently. Three DPs were identified by GC-MS through the structural information provided by full scan mass spectra obtained by electron impact (EI) ionization and two more by HPLC-DAD by comparing the retention times (t(R)) and the UV spectra of the unknown DPs with those of commercial standards. Based on this by-product identification a possible multi-step degradation scheme was proposed. The pathways include single or multiple hydroxylation of BZF with subsequent phenoxy ring opening and the cleavage of the amide and ether bonds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
1183
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-48
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Identification of photocatalytic degradation products of bezafibrate in TiO(2) aqueous suspensions by liquid and gas chromatography.
pubmed:affiliation
Department of Chemistry, University of Ioannina, Ioannina, Greece.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't