Linked Life Data

18241688

Source:http://linkedlifedata.com/resource/pubmed/id/18241688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Suppl
pubmed:dateCreated
2008-2-4
pubmed:abstractText
The immune system can be adversely affected by a variety of extrinsic factors, including immunosuppressive drugs, exposure to harsh environmental conditions, hereditary disorders other than primary immunodeficiencies, and acquired metabolic disorders such as diabetic mellitus, with all of these resulting in conditions known as secondary immunodeficiencies. Perhaps the most well known secondary immunodeficiency is caused by HIV infection; however, the most prevalent cause of immunodeficiency worldwide is severe malnutrition, which affects as much as 50% of the population in some impoverished communities. The abnormalities of the immune system induced by secondary immunodeficiencies affect both the innate and the adaptive immunity, may be subtle, and are usually heterogeneous in their clinical manifestations. Treatment of the primary condition often results in the improvement of the compromised immune components of the disease complex. This article updates the concepts of some of the major categories of conditions that can potentially suppress the immune response, including HIV disease, to provide a conceptual frame to assess patients with suspected secondary deficiencies of the immune system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-6825
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S388-92; quiz S417
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
6. Secondary immunodeficiencies, including HIV infection.
pubmed:affiliation
Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates St. Houston, TX 77030, USA. jxchinen@texaschildrenshospital.org
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural