Linked Life Data

18241669

Source:http://linkedlifedata.com/resource/pubmed/id/18241669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-21
pubmed:abstractText
Inositol 1,4,5-trisphosphate receptor (IP(3)R) plays a crucial role in generating Ca(2+) signaling and three subtypes of IP(3)R have been identified. In spite of a high degree of similarity among these subtypes, their effects on spatio-temporal Ca(2+) patterns are specific and diverse; therefore the physiological significance of the differential expression levels of IP(3)R subtypes in various tissues remains unknown. Here, we examined the relative contribution of the specific subtype of IP(3)Rs to the agonist-induced Ca(2+) signaling and contraction in IP(3)R-deficient vascular smooth muscle cells and found that IP(3)R1 deficient cells exclusively showed less sensitivity to the agonist, compared to those from the other genotypes. We also found that IP(3)R1 dominantly expressed in vascular aortae on a consistent basis, and that phenylephrine (PE)-induced aortic muscle contraction was reduced specifically in IP(3)R1-deficient aortae. Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
369
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.
pubmed:affiliation
Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't