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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-6
pubmed:abstractText
Ulcerative colitis (UC) is a multi-factorial inflammatory disease of the colon and rectum. The present study was undertaken to investigate the effect of taurine, an anti-oxidant amino acid, on oxidative stress and the expression of apoptosis-related proteins, pro-apoptotic Bax and anti-apoptotic B cell lymphoma-2 (Bcl-2) in colon tissue in rats with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Rats received taurine (1.5% w/v) in drinking water for 15 days before and 15 days after administration of TNBS solution. Then, colonic myeloperoxidase (MPO) activity, malondialdehyde (MDA) and glutathione (GSH) levels, and Bax and Bcl-2 expression were measured. TNBS-induced colitis caused significantly increased MPO activity and MDA levels and decreased GSH levels in colon tissue compared to controls. Increase in Bax expression and decrease in Bcl-2 expression were detected in colon of rats with TNBS-induced colitis. Taurine treatment was associated with amelioration in macroscopic and microscopic colitis scores, decreased colonic MPO activity and MDA levels and increased GSH levels in TNBS-induced colitis. In addition, taurine reduced the expression of Bax and prevented the loss of Bcl-2 proteins in colon tissue of rats with TNBS-induced colitis. The results of this study show that taurine administration may exert beneficial effects in UC by decreasing inflammatory reactions, oxidative stress and apoptosis.
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1365-2249
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:18241224-Animals, pubmed-meshheading:18241224-Apoptosis, pubmed-meshheading:18241224-Apoptosis Regulatory Proteins, pubmed-meshheading:18241224-Blotting, Western, pubmed-meshheading:18241224-Colitis, Ulcerative, pubmed-meshheading:18241224-Colon, pubmed-meshheading:18241224-Disease Models, Animal, pubmed-meshheading:18241224-Glutathione, pubmed-meshheading:18241224-Male, pubmed-meshheading:18241224-Malondialdehyde, pubmed-meshheading:18241224-Oxidative Stress, pubmed-meshheading:18241224-Peroxidase, pubmed-meshheading:18241224-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:18241224-Rats, pubmed-meshheading:18241224-Rats, Wistar, pubmed-meshheading:18241224-Taurine, pubmed-meshheading:18241224-Trinitrobenzenesulfonic Acid, pubmed-meshheading:18241224-bcl-2-Associated X Protein
pubmed:year
2008
pubmed:articleTitle
Effect of taurine on oxidative stress and apoptosis-related protein expression in trinitrobenzene sulphonic acid-induced colitis.
pubmed:affiliation
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
pubmed:publicationType
Journal Article
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