Source:http://linkedlifedata.com/resource/pubmed/id/18241079
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2008-3-24
|
| pubmed:abstractText |
The CpG island methylator phenotype (CIMP) in colorectal tumours can be recognized by an increased frequency of aberrant methylation in a specific set of genomic loci. Because of the strong association of CIMP with high microsatellite instability (MSI-H), the identification of CIMP+ tumours within microsatellite stable (MSS) colorectal cancers may not be straightforward. To overcome this potential limitation, we have built an improved seven-locus set of methylation markers that includes CACNA1G, IGF2, RUNX3, HTR6, RIZ1, MINT31, and MAP1B. This new set of CIMP markers revealed a bimodal distribution of methylation frequencies in a group of 95 MSS colorectal cancers, which allowed a clearer separation between CIMP classes. Correlation of MSS CIMP+ tumours with bio-pathological traits revealed significant associations with location to the proximal colon, mucinous histology, BRAF mutation, and chromosomal stability. A potential trend towards an adverse prognosis of CIMP+ cases was associated with the high frequency of BRAF mutations present within this cohort of tumours. Microarray analysis revealed that CIMP+ tumours are characterized by a unique expression profile, a result that confirms that CIMP+ tumours represent a truly distinct molecular class within MSS colorectal cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-3417
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2008 Pathological Society of Great Britain and Ireland
|
| pubmed:issnType |
Print
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| pubmed:volume |
214
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
594-602
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18241079-Aged,
pubmed-meshheading:18241079-Cluster Analysis,
pubmed-meshheading:18241079-Colorectal Neoplasms,
pubmed-meshheading:18241079-CpG Islands,
pubmed-meshheading:18241079-DNA, Neoplasm,
pubmed-meshheading:18241079-DNA Methylation,
pubmed-meshheading:18241079-Disease-Free Survival,
pubmed-meshheading:18241079-Female,
pubmed-meshheading:18241079-Gene Expression Profiling,
pubmed-meshheading:18241079-Genetic Markers,
pubmed-meshheading:18241079-Humans,
pubmed-meshheading:18241079-Male,
pubmed-meshheading:18241079-Microsatellite Instability,
pubmed-meshheading:18241079-Microsatellite Repeats,
pubmed-meshheading:18241079-Mutation,
pubmed-meshheading:18241079-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18241079-Phenotype,
pubmed-meshheading:18241079-Prognosis,
pubmed-meshheading:18241079-Proto-Oncogene Proteins B-raf
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.
|
| pubmed:affiliation |
Dipartimento di Medicina Sperimentale e Diagnostica, Università di Ferrara, via Luigi Borsari 46, 44100 Ferrara, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|