Linked Life Data

18240383

Source:http://linkedlifedata.com/resource/pubmed/id/18240383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-30
pubmed:abstractText
A chemoselective reaction between oxyamines and unprotected, unactivated reducing sugars was used to construct for the first time a panel of linkage-diversified neoglycosides. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage. These results validate linkage diversification through neoglycosylation as a unique and simple strategy to powerfully complement existing methods for the optimization of glycoconjugates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
670-3
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins.
pubmed:affiliation
Department of Chemistry, Seattle University, 901 12th Avenue, Seattle, WA 98122, USA. langenha@seattleu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't