Linked Life Data

18240299

Source:http://linkedlifedata.com/resource/pubmed/id/18240299

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-9-3
pubmed:abstractText
The objective was to evaluate stratum corneum lipid liposomes (SCLLs) prepared from commercial lipids as a convenient model system for studying the mechanisms of chemical permeation enhancers. Liposomes prepared from extracted stratum corneum lipids (ESCLLs) were used as a control. Three different types of SCLLs were prepared by sonication or extrusion from mixtures of commercial ceramides, cholesterol, free fatty acids, and cholesterol 3-sulfate (SCLL-I-III; 55/25/15/5 weight ratio). Absolute mannitol permeabilities were 5- to 20-fold lower in SCLLs than in ESCLLs. 1-alkyl-2-pyrrolidone enhancers produced the same enhancement factor for mannitol efflux in sonicated SCLLs (SCLL-I) as reported previously for the ESCLLs. Enhancer-induced changes at graded depths were further monitored in SCLL-I vesicles using fluorescence spectroscopy with n-(9-anthroyloxy) fatty acid fluorescent probes. Lipid packing order, as determined from rotational correlation times derived from steady-state anisotropy and lifetime data, was found to be higher in SCLL-I than in ESCLLs. 1-alkyl-2-pyrrolidones were found to increase the fluidity of the bilayers to approximately the same extent at intermediate depths (C6-C9) as previously reported for the ESCLLs. The present results demonstrate that the sonicated SCLL model may be useful for studying the mechanisms of action of transdermal permeation enhancers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1520-6017
pubmed:author
pubmed:copyrightInfo
(c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association
pubmed:issnType
Electronic
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4278-93
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids.
pubmed:affiliation
Department of Pharmaceutics, University of Kuopio, Kuopio, Finland. marjukka.suhonen@uku.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural