Source:http://linkedlifedata.com/resource/pubmed/id/18239580
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-4-1
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| pubmed:abstractText |
Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies. The studies included a random sample of the Utah population, families selected for aggregation of extreme thinness, families selected for severe obesity, a series of unrelated severe obesity subjects, and families participating in a 25-year longitudinal study of cardiovascular disease and aging. Results show a strong significant increase in the rs9939609 A allele frequency with increasing BMI (P < 0.0001). In the longitudinal study, FTO genotypes were significantly associated with BMI at a baseline exam, a 2(1/2)-year follow-up exam and a 25-year follow-up exam using an additive genetic model. The mean genotype difference in BMI ranged from 1.3 to 2.1 kg/m(2) across exams. The genotype difference in BMI means was established in youth, and at-risk subjects under age 20 at baseline had a significantly larger 25-year BMI increase (10.0 for A/A; 9.7 for A/T, and 8.5 kg/m(2) for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
902-4
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| pubmed:meshHeading |
pubmed-meshheading:18239580-Adolescent,
pubmed-meshheading:18239580-Adult,
pubmed-meshheading:18239580-Aged,
pubmed-meshheading:18239580-Aged, 80 and over,
pubmed-meshheading:18239580-Aging,
pubmed-meshheading:18239580-Body Mass Index,
pubmed-meshheading:18239580-Cardiovascular Diseases,
pubmed-meshheading:18239580-Child,
pubmed-meshheading:18239580-Child, Preschool,
pubmed-meshheading:18239580-Female,
pubmed-meshheading:18239580-Follow-Up Studies,
pubmed-meshheading:18239580-Gene Frequency,
pubmed-meshheading:18239580-Genetic Predisposition to Disease,
pubmed-meshheading:18239580-Genotype,
pubmed-meshheading:18239580-Humans,
pubmed-meshheading:18239580-Male,
pubmed-meshheading:18239580-Middle Aged,
pubmed-meshheading:18239580-Obesity,
pubmed-meshheading:18239580-Pedigree,
pubmed-meshheading:18239580-Polymorphism, Single Nucleotide,
pubmed-meshheading:18239580-Proteins,
pubmed-meshheading:18239580-Utah
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| pubmed:year |
2008
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| pubmed:articleTitle |
Association of the FTO gene with BMI.
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| pubmed:affiliation |
Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA. steve.hunt@utah.edu
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| pubmed:publicationType |
Journal Article
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