18234639

Source:http://linkedlifedata.com/resource/pubmed/id/18234639

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0087111, umls-concept:C0239946, umls-concept:C0600388, umls-concept:C0681814, umls-concept:C1948041
pubmed:issue	1
pubmed:dateCreated	2008-1-31
pubmed:abstractText	The pathogenesis of hepatic fibrosis and cirrhosis is still not fully understood. The extracellular signal-regulated kinase (ERK) pathway is involved in the regulation of cell proliferation and differentiation. The aim of this study was to investigate the effects of PD98059, a specific inhibitor of ERK, on the cell cycle, cell proliferation, secretion of type I collagen and expression of cyclin D1 mRNA, CDK4 mRNA and transforming growth factor-beta1 (TGF-beta1) mRNA in rat hepatic stellate cells (HSCs) stimulated by acetaldehyde.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101151457
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acetaldehyde, http://linkedlifedata.com/resource/pubmed/chemical/Cdk4 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/PD 98059, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1499-3872
pubmed:author	pubmed-author:JiangMing-DeMD, pubmed-author:QinJian-PingJP, pubmed-author:SunHao-PingHP, pubmed-author:WangYun-XiaYX, pubmed-author:WuXiao-LingXL, pubmed-author:XuHuiH, pubmed-author:ZengWei-ZhengWZ, pubmed-author:ZhangYongY, pubmed-author:ZhengShu-MeiSM
pubmed:issnType	Print
pubmed:volume	7
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	51-7
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18234639-Acetaldehyde, pubmed-meshheading:18234639-Animals, pubmed-meshheading:18234639-Cells, Cultured, pubmed-meshheading:18234639-Collagen Type I, pubmed-meshheading:18234639-Cyclin D1, pubmed-meshheading:18234639-Cyclin-Dependent Kinase 4, pubmed-meshheading:18234639-Enzyme Inhibitors, pubmed-meshheading:18234639-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:18234639-Flavonoids, pubmed-meshheading:18234639-G0 Phase, pubmed-meshheading:18234639-G1 Phase, pubmed-meshheading:18234639-Hepatocytes, pubmed-meshheading:18234639-Liver Cirrhosis, pubmed-meshheading:18234639-MAP Kinase Signaling System, pubmed-meshheading:18234639-RNA, Messenger, pubmed-meshheading:18234639-Rats, pubmed-meshheading:18234639-Rats, Inbred Strains, pubmed-meshheading:18234639-Transforming Growth Factor beta1
pubmed:year	2008
pubmed:articleTitle	An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.
pubmed:affiliation	Department of Gastroenterology, General Hospital of Chengdu Military Command, Chengdu 610083, China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't