| pubmed-article:18234356 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18234356 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18234356 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:18234356 | pubmed:dateCreated | 2008-4-21 | lld:pubmed |
| pubmed-article:18234356 | pubmed:abstractText | To investigate CD8+ regulatory T cell influence on multiple sclerosis development, peripheral blood and cerebrospinal fluid (CSF) CD8+ T cell clones (TCCs) recognizing MBP(83-102) and MOG(63-87)-specific CD4+ T cells were isolated from 20 patients during acute exacerbations, 15 in remission and 15 controls. Blood and CSF CD8+ regulatory TCC cloning frequency decreased more during exacerbations than remissions or controls. Target cell pre-activation significantly enhanced CD8+ T granule-mediated cell killing of CD4+ targets, and was restricted by HLA-E. During exacerbations, killer-inhibitory receptor CD94/NKG2A expression was significantly higher in CD8+ TCCs, limiting their cytotoxic activity. Moreover, IL-15 and IFN-gamma significantly increased CD94 and NKG2A expression. These data provide evidence that CD94/NKG2A receptors play an important role in regulating T cell activity during the course of MS. | lld:pubmed |
| pubmed-article:18234356 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18234356 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18234356 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18234356 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18234356 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18234356 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:18234356 | pubmed:author | pubmed-author:CorrealeJorge... | lld:pubmed |
| pubmed-article:18234356 | pubmed:author | pubmed-author:VillaAndrésA | lld:pubmed |
| pubmed-article:18234356 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18234356 | pubmed:volume | 195 | lld:pubmed |
| pubmed-article:18234356 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18234356 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18234356 | pubmed:pagination | 121-34 | lld:pubmed |
| pubmed-article:18234356 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18234356 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18234356 | pubmed:articleTitle | Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis. | lld:pubmed |
| pubmed-article:18234356 | pubmed:affiliation | Department of Neurology, Raúl Carrea Institute for Neurological Research, FLENI, Montañeses 2325, (1428) Buenos Aires, Argentina. jcorreale@fleni.org.ar | lld:pubmed |
| pubmed-article:18234356 | pubmed:publicationType | Journal Article | lld:pubmed |
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