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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-4-21
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pubmed:abstractText |
To investigate CD8+ regulatory T cell influence on multiple sclerosis development, peripheral blood and cerebrospinal fluid (CSF) CD8+ T cell clones (TCCs) recognizing MBP(83-102) and MOG(63-87)-specific CD4+ T cells were isolated from 20 patients during acute exacerbations, 15 in remission and 15 controls. Blood and CSF CD8+ regulatory TCC cloning frequency decreased more during exacerbations than remissions or controls. Target cell pre-activation significantly enhanced CD8+ T granule-mediated cell killing of CD4+ targets, and was restricted by HLA-E. During exacerbations, killer-inhibitory receptor CD94/NKG2A expression was significantly higher in CD8+ TCCs, limiting their cytotoxic activity. Moreover, IL-15 and IFN-gamma significantly increased CD94 and NKG2A expression. These data provide evidence that CD94/NKG2A receptors play an important role in regulating T cell activity during the course of MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-34
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18234356-Adult,
pubmed-meshheading:18234356-Antigens, CD28,
pubmed-meshheading:18234356-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18234356-Cell Proliferation,
pubmed-meshheading:18234356-Cells, Cultured,
pubmed-meshheading:18234356-Cytokines,
pubmed-meshheading:18234356-Female,
pubmed-meshheading:18234356-Flow Cytometry,
pubmed-meshheading:18234356-Granzymes,
pubmed-meshheading:18234356-Humans,
pubmed-meshheading:18234356-Lymphocyte Activation,
pubmed-meshheading:18234356-Male,
pubmed-meshheading:18234356-Middle Aged,
pubmed-meshheading:18234356-Multiple Sclerosis, Relapsing-Remitting,
pubmed-meshheading:18234356-Myelin Basic Proteins,
pubmed-meshheading:18234356-NK Cell Lectin-Like Receptor Subfamily C,
pubmed-meshheading:18234356-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:18234356-Peptide Fragments,
pubmed-meshheading:18234356-Perforin,
pubmed-meshheading:18234356-Receptors, Immunologic,
pubmed-meshheading:18234356-Receptors, Natural Killer Cell,
pubmed-meshheading:18234356-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:18234356-T-Lymphocytes, Regulatory
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pubmed:year |
2008
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pubmed:articleTitle |
Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis.
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pubmed:affiliation |
Department of Neurology, Raúl Carrea Institute for Neurological Research, FLENI, Montañeses 2325, (1428) Buenos Aires, Argentina. jcorreale@fleni.org.ar
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pubmed:publicationType |
Journal Article
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