Linked Life Data

18232415

Source:http://linkedlifedata.com/resource/pubmed/id/18232415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-1-31
pubmed:abstractText
A common measure of the relative toxicity is the ratio of median lethal doses for responses estimated in two bioassays. Robertson and Preisler previously proposed a method for constructing a confidence interval for the ratio. The applicability of this technique in common experimental situations, especially those involving small samples, may be questionable because the sampling distribution of this ratio estimator may be highly skewed. To examine this possibility, we did a computer simulation experiment to evaluate the coverage properties of the Robertson and Preisler method. The simulation showed that the method provided confidence intervals that performed at the nominal confidence level for the range of responses often observed in pesticide bioassays. Results of this study provide empirical support for the continued use this technique.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-0493
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1945-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Confidence interval construction for relative toxicity endpoints such as LD50 or LD90 ratios.
pubmed:affiliation
Risk Education Branch, National Institutional for Occupational Safety and Health, 4676 Columbia Pkwy., Cincinnati, OH 45226, USA. mwheeler@cdc.gov
pubmed:publicationType
Journal Article