Linked Life Data

1823172

Source:http://linkedlifedata.com/resource/pubmed/id/1823172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-9-23
pubmed:abstractText
Considerable interest has been shown in developing a magnetic resonance (MR) imaging technique with quantitative capability in the evaluation of tissue microcirculation ("perfusion"). In the present study, the flow-dephased/flow-compensated (FD/FC) technique is evaluated for measuring rat cerebral blood flow (CBF) under nearly optimal laboratory conditions. Imaging was performed on a 2.0-T system equipped with shielded gradient coils. Rat CBF was varied by manipulating arterial carbon dioxide pressure (PaCO2). In parallel experiments, optimized MR imaging studies (seven rats) were compared with laser Doppler flowmetry (LDF) studies (nine rats). LDF values showed a high degree of correlation between CBF and PaCO2, agreeing with results in the literature. MR imaging values, while correlating with PaCO2, showed considerable scatter. The most likely explanation is unavoidable rat motion during the requisite long imaging times. Because of this motion sensitivity, the FD/FC technique cannot provide a quantitative measure of CBF. It can, however, provide a qualitative picture.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1053-1807
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
673-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.
pubmed:affiliation
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.