Linked Life Data

18230365

Source:http://linkedlifedata.com/resource/pubmed/id/18230365

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-3-31
pubmed:abstractText
It is an important therapeutic strategy to protect mitochondria from oxidative stress, especially during ischemia-reperfusion. In the present study, an attempt has been made to evaluate the protective effects of caffeic acid phenethyl ester (CAPE) and its related phenolic compounds on mouse brain and liver mitochondria injury induced by in vitro anoxia-reoxygenation. Added before anoxia or reoxygenation, CAPE markedly protected coupled respiration with the decrease in state 4 and the increases in state 3, respiratory control ratio (RCR) and ADP/O ratio in a concentration-dependent manner. CAPE effectively protected mitochondria by inhibiting the mitochondrial membranes fluidity decrease, the lipoperoxidation and the protein carbonylation increase, which indicated its protective action against the mitochondrial oxidative damage. Meanwhile, CAPE blocked the enhanced release of cardiolipin (CL) and cytochrome c (Cyt c). The related phenolic compounds like caffeic acid (CA), ferulic acid (FA) and ethyl ferulate (EF) also had different-degree protective effects. CAPE and CA were more potent than FA and EF. Their structural differences played the key role in their activity levels. These results suggest that CAPE and its related phenolic compounds protect mitochondria mainly correlated to their antioxidative activities and may be of interest for the prevention and therapy of ischemia-reperfusion injuries.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1780
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
659-72
pubmed:meshHeading
pubmed-meshheading:18230365-Anaerobiosis, pubmed-meshheading:18230365-Animals, pubmed-meshheading:18230365-Anisotropy, pubmed-meshheading:18230365-Antioxidants, pubmed-meshheading:18230365-Brain, pubmed-meshheading:18230365-Caffeic Acids, pubmed-meshheading:18230365-Coumaric Acids, pubmed-meshheading:18230365-Cytochromes c, pubmed-meshheading:18230365-Dose-Response Relationship, Drug, pubmed-meshheading:18230365-Male, pubmed-meshheading:18230365-Mice, pubmed-meshheading:18230365-Mitochondria, pubmed-meshheading:18230365-Mitochondria, Liver, pubmed-meshheading:18230365-Mitochondrial Membranes, pubmed-meshheading:18230365-Molecular Structure, pubmed-meshheading:18230365-Oxygen, pubmed-meshheading:18230365-Phenylethyl Alcohol, pubmed-meshheading:18230365-Thiobarbituric Acid Reactive Substances
pubmed:year
2008
pubmed:articleTitle
Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia-reoxygenation: relationship to their antioxidant activities.
pubmed:affiliation
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tianshui South Road, Lanzhou, 730000, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't