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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-2-28
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pubmed:abstractText |
Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Evidence suggests that MSI/CIMP+ colorectal cancer may arise through the serrated tumorigenic pathway through various forms of serrated neoplasias. Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18230181-Adenoma,
pubmed-meshheading:18230181-Aged,
pubmed-meshheading:18230181-Cohort Studies,
pubmed-meshheading:18230181-Colonic Polyps,
pubmed-meshheading:18230181-Colorectal Neoplasms,
pubmed-meshheading:18230181-Cyclooxygenase 2,
pubmed-meshheading:18230181-Female,
pubmed-meshheading:18230181-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18230181-Humans,
pubmed-meshheading:18230181-Hyperplasia,
pubmed-meshheading:18230181-Male,
pubmed-meshheading:18230181-Middle Aged,
pubmed-meshheading:18230181-Prospective Studies
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pubmed:year |
2008
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pubmed:articleTitle |
Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma.
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pubmed:affiliation |
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. takako_kawasaki@dfci.harvard.edu
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