Linked Life Data

18227531

Source:http://linkedlifedata.com/resource/pubmed/id/18227531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-14
pubmed:abstractText
The methionine choline-deficient (MCD) diet results in liver injury similar to human nonalcoholic steatohepatitis (NASH). The aims of this study were to define mechanisms of MCD-induced steatosis in insulin-resistant db/db and insulin-sensitive db/m mice. MCD-fed db/db mice developed more hepatic steatosis and retained more insulin resistance than MCD-fed db/m mice. Both subcutaneous and gonadal fat were reduced by MCD feeding: gonadal fat decreased by 23% in db/db mice and by 90% in db/m mice. Weight loss was attenuated in the db/db mice, being only 13% compared with 35% in MCD-fed db/db and db/m mice, respectively. Both strains had upregulation of hepatic fatty acid transport proteins as well as increased hepatic uptake of [14C]oleic acid: 3-fold in db/m mice (P < 0.001) and 2-fold in db/db mice (P < 0.01) after 4 weeks of MCD feeding. In both murine strains, the MCD diet reduced triglyceride secretion and downregulated genes involved in triglyceride synthesis. Therefore, increased fatty acid uptake and decreased VLDL secretion represent two important mechanisms by which the MCD diet promotes intrahepatic lipid accumulation in this model. Feeding the MCD diet to diabetic rodents broadens the applicability of this model for the study of human NASH.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-10051466, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-10553017, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-10593920, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-11090130, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-11266382, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-11459853, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-11580141, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-11994399, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-12127425, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-12746274, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-14672613, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-14697954, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-14984364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15030975, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15044174, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15066988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15122757, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15123680, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15166226, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15256362, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15582125, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15632182, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-15864352, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16248953, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16265100, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16265231, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16285964, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16317688, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16374858, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16618416, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16804073, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-16829692, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-17075577, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-17103053, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-17241878, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-17476695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-2691570, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-3343237, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-3904950, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-7742355, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-9254055, http://linkedlifedata.com/resource/pubmed/commentcorrection/18227531-9671728
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1068-76
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet.
pubmed:affiliation
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. m-rinella@northwestern.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't
More...