Source:http://linkedlifedata.com/resource/pubmed/id/18226823
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-2-25
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| pubmed:abstractText |
Four polyhydroxylated and polyunsaturated furostanol glycosides (1-4), named caucasicosides A (1), B (2), C (3) and D (4), were isolated from the MeOH extract of the underground parts of Helleborus caucasicus, along with four spirostanol derivatives, a furostanol glycoside, a furospirostanol glycoside, 20-hydroxyecdysone and the bufadienolides hellebrigenin and deglucohellebrin. The structures of 1-4 were elucidated as furosta-5,20(22),25(27)-triene-1beta,3beta,11alpha,26-tetrol 26-O-beta-D-glucopyranoside (1), 26-O-beta-D-glucopyranosylfurosta-5,20(22),25(27)-triene-1beta,3beta,11alpha,26-tetrol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (2), 26-O-beta-d-glucopyranosyl-22alpha-methoxyfurosta-5,25(27)-diene-1beta,3beta,11alpha,26-tetrol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (3), 26-O-beta-D-glucopyranosylfurosta-5,20(22),25(27)-triene-1beta,3beta,26-triol 3-O-beta-D-xylopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-4-O-sulfo-alpha-L-arabinopyranoside (4). Structure elucidation was accomplished through the extensive use of 1D- and 2D NMR experiments including 1H-1H (COSY, 1D-TOCSY) and 1H-13C (HSQC, HMBC) spectroscopy along with ESI-MS and HR-ESI-MS. The aglycones of 1-4 have never been reported before.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0031-9422
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
69
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1227-33
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| pubmed:meshHeading |
pubmed-meshheading:18226823-Glycosides,
pubmed-meshheading:18226823-Helleborus,
pubmed-meshheading:18226823-Hydrolysis,
pubmed-meshheading:18226823-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18226823-Molecular Conformation,
pubmed-meshheading:18226823-Plant Roots,
pubmed-meshheading:18226823-Reference Standards,
pubmed-meshheading:18226823-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:18226823-Stereoisomerism,
pubmed-meshheading:18226823-Steroids,
pubmed-meshheading:18226823-Sulfates
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| pubmed:year |
2008
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| pubmed:articleTitle |
Steroidal glycosides from the underground parts of Helleborus caucasicus.
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| pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy.
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| pubmed:publicationType |
Journal Article
|