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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-3-10
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pubmed:abstractText |
The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders. Although artemisinin-based combination therapy has been recommended for the treatment of multidrug-resistant falciparum malaria, these combinations are not available for some people, such as travelers from North America. A fixed-dose combination of atovaquone and proguanil (Malarone) has been proved to be effective for the treatment and prophylaxis of malaria which is already approved by countries in North America and Europe. Determination of the phenotypes and genotypes related to atovaquone/proguanil response in Thai isolates of P. falciparum will be useful for rationale drug use. The main purpose of this study was to explore the in vitro atovaquone/proguanil susceptibility of recently adapted Thai isolates of P. falciparum. Genotypic characterization of the cytb gene of these isolates was also determined since it has been reported that point mutations, particularly codon 268 in the cytochrome b gene (cytb) have been linked to atovaquone/proguanil treatment failure.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-10348748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-10898682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-12057021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-12649236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-12665429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-12884171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-14723376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-1516668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-15478057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-15718226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-15827276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-16235366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-16319183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-16451346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-16690094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-16962361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-17020611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-17298921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-17426165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-394674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-781840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-8050525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-9020100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18226262-9129535
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18226262-Animals,
pubmed-meshheading:18226262-Antimalarials,
pubmed-meshheading:18226262-Atovaquone,
pubmed-meshheading:18226262-Codon,
pubmed-meshheading:18226262-Cytochromes b,
pubmed-meshheading:18226262-Drug Resistance, Multiple,
pubmed-meshheading:18226262-Genes, Protozoan,
pubmed-meshheading:18226262-Malaria, Falciparum,
pubmed-meshheading:18226262-Parasitic Sensitivity Tests,
pubmed-meshheading:18226262-Plasmodium falciparum,
pubmed-meshheading:18226262-Point Mutation,
pubmed-meshheading:18226262-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:18226262-Proguanil,
pubmed-meshheading:18226262-Protozoan Proteins,
pubmed-meshheading:18226262-Thailand
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pubmed:year |
2008
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pubmed:articleTitle |
In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.
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pubmed:affiliation |
Department of Parasitology, Phramongkutklao College of Medicine, Ratchawithi Rd, Bangkok 10400, Thailand. kik_kuru@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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