Linked Life Data

18226232

Source:http://linkedlifedata.com/resource/pubmed/id/18226232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-2-22
pubmed:abstractText
Sarcoidosis is a multisystem disease characterized by noncaseating granulomas in the lungs, skin, lymph nodes, and, rarely, the nervous system. Granuloma formation in sarcoidosis is mediated by increased secretion of interferon-gamma, interleukin-2, and tumor necrosis factor-alpha. 25% of patients with neurosarcoidosis are steroid resistant and another 20-40% are resistant to any conventional immunosuppression, but the typical agents suppress the immune system in a non-specific fashion. Thalidomide has been shown to have activity specific to the inflammatory mediators of sarcoidosis, has been shown to be beneficial in cutaneous sarcoidosis, and provides an interesting observation in our patient with refractory neurosarcoidosis.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1752-1947
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27
pubmed:year
2008
pubmed:articleTitle
Prognosis of refractory neurosarcoidosis altered by thalidomide: a case report.
pubmed:affiliation
Dardinger Neuro-Oncology Center, Division of Neuro-Oncology, and Department of Neurology, The Ohio State University Medical Center and James Cancer Hospital & Solove Research Institute, Columbus, Ohio, USA. chad.hoyle@osumc.edu
pubmed:publicationType
Journal Article