| pubmed-article:18223652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C1416991 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C1420799 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C1818972 | lld:lifeskim |
| pubmed-article:18223652 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18223652 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18223652 | pubmed:dateCreated | 2008-2-20 | lld:pubmed |
| pubmed-article:18223652 | pubmed:abstractText | The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling. | lld:pubmed |
| pubmed-article:18223652 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18223652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18223652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18223652 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18223652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18223652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18223652 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18223652 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:MarynenPeterP | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:SunLijunL | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:BeyaertRudiR | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:HeyninckKaren... | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:ChenZhijian... | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:BaensMathijsM | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:StaalJensJ | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:HaegmanMiraM | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:CoornaertBeat... | lld:pubmed |
| pubmed-article:18223652 | pubmed:author | pubmed-author:BekaertTineT | lld:pubmed |
| pubmed-article:18223652 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18223652 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18223652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18223652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18223652 | pubmed:pagination | 263-71 | lld:pubmed |
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| pubmed-article:18223652 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18223652 | pubmed:articleTitle | T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. | lld:pubmed |
| pubmed-article:18223652 | pubmed:affiliation | Department of Molecular Biology, Ghent University, B-9052 Ghent, Belgium. | lld:pubmed |
| pubmed-article:18223652 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18223652 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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