rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-20
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pubmed:abstractText |
The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MALT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/TNFAIP3 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1529-2916
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-71
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pubmed:meshHeading |
pubmed-meshheading:18223652-Caspases,
pubmed-meshheading:18223652-Cell Line,
pubmed-meshheading:18223652-Humans,
pubmed-meshheading:18223652-Immunoblotting,
pubmed-meshheading:18223652-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18223652-Jurkat Cells,
pubmed-meshheading:18223652-Lymphocyte Activation,
pubmed-meshheading:18223652-NF-kappa B,
pubmed-meshheading:18223652-Neoplasm Proteins,
pubmed-meshheading:18223652-Nuclear Proteins,
pubmed-meshheading:18223652-Peptide Hydrolases,
pubmed-meshheading:18223652-Receptors, Antigen, T-Cell,
pubmed-meshheading:18223652-Signal Transduction,
pubmed-meshheading:18223652-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
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pubmed:affiliation |
Department of Molecular Biology, Ghent University, B-9052 Ghent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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