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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-28
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pubmed:abstractText |
Tamoxifen remains therapy of choice for premenopausal estrogen receptor alpha-positive breast cancer. However, resistance and recurrence are serious problems. Our previous work indicated that carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) was significantly up-regulated in tamoxifen-resistant (TAMr) MCF-7 derivatives. The aim of this study was to determine the functional role of CEACAM6 in endocrine-resistant breast cancer and to retrospectively test whether it was predictive of resistance in a large cohort of breast cancers with long-term follow-up.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxytamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/CEACAM6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18223215-Antigens, CD,
pubmed-meshheading:18223215-Antineoplastic Agents, Hormonal,
pubmed-meshheading:18223215-Breast,
pubmed-meshheading:18223215-Breast Neoplasms,
pubmed-meshheading:18223215-Cell Adhesion Molecules,
pubmed-meshheading:18223215-Cell Line, Tumor,
pubmed-meshheading:18223215-Cell Proliferation,
pubmed-meshheading:18223215-Chemotherapy, Adjuvant,
pubmed-meshheading:18223215-Drug Resistance, Neoplasm,
pubmed-meshheading:18223215-Estradiol,
pubmed-meshheading:18223215-Estrogen Antagonists,
pubmed-meshheading:18223215-GPI-Linked Proteins,
pubmed-meshheading:18223215-Humans,
pubmed-meshheading:18223215-Neoplasm Recurrence, Local,
pubmed-meshheading:18223215-Prognosis,
pubmed-meshheading:18223215-RNA Interference,
pubmed-meshheading:18223215-Selective Estrogen Receptor Modulators,
pubmed-meshheading:18223215-Tamoxifen,
pubmed-meshheading:18223215-Tissue Array Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen.
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pubmed:affiliation |
Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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