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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-8-4
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pubmed:abstractText |
Prostaglandin E2 (PGE2) is a potent immune modulator and known to suppress both tumour antigen-specific helper T (TH1) cells and the generation of cytotoxic T lymphocytes (CTLs). We hypothesised that a combination of the cyclooxygenase 2 (COX-2) selective inhibitor celecoxib and intravesical bacillus Calmette-Guérin (BCG), an effective tumour immunoprophylaxis and ablative therapy for non-muscle-invasive bladder cancer, would be more effective than BCG alone.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0302-2838
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
621-30
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pubmed:meshHeading |
pubmed-meshheading:18222600-Analysis of Variance,
pubmed-meshheading:18222600-Animals,
pubmed-meshheading:18222600-BCG Vaccine,
pubmed-meshheading:18222600-Blotting, Western,
pubmed-meshheading:18222600-Carcinoma, Transitional Cell,
pubmed-meshheading:18222600-Cyclooxygenase Inhibitors,
pubmed-meshheading:18222600-Dinoprostone,
pubmed-meshheading:18222600-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18222600-Humans,
pubmed-meshheading:18222600-Immunotherapy,
pubmed-meshheading:18222600-Mice,
pubmed-meshheading:18222600-Pyrazoles,
pubmed-meshheading:18222600-Sulfonamides,
pubmed-meshheading:18222600-Treatment Outcome,
pubmed-meshheading:18222600-Up-Regulation,
pubmed-meshheading:18222600-Urinary Bladder Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma.
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pubmed:affiliation |
Department of Surgery/Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle-Upon-Tyne, United Kingdom. SDovedi@PICR.man.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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